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Name	Diseases	Agents	Affected areas
Abdominal cramp	Clostridial myonecrosis	Clostridium perfringens N/S Delta toxin	Integumentary (null) Digestive system (null)
Abdominal pain	Gastroenteritis	Norovirus norwalk virus Boxer Norovirus norwalk virus BUDS Norovirus norwalk virus GrV Norovirus norwalk virus GrV or VA207 Norovirus norwalk virus HV Norovirus norwalk virus MOH Norovirus norwalk virus MxV Norovirus norwalk virus NV Norovirus norwalk virus OIF Norovirus norwalk virus PiV Norovirus norwalk virus VA207 Norovirus norwalk virus VA387 Rotavirus Human rotavirus P[14] HAL1166 Rotavirus Unclassified Rotavirus A RRV Norovirus norwalk virus GII.12 Rotavirus Bovine rotavirus A NCDV/G6 Rotavirus Human Rotavirus A Human Rotavirus G3P[6] Rotavirus Simian rotavirus A SA11 Rotavirus Bovine rotavirus A UK/G6	Small intestine (Human) Colonic epithelium (Human)
Anemia	Malaria	Plasmodium falciparum N/S Plasmodium falciparum N/S Plasmodium falciparum N/S	Unknown (null)
Anoxia	Pertussis	Bordetella pertussis Bordetella pertussis N/S Bordetella pertussis N/S Toxin	Unknown (null)
Arthritis	Lyme disease	Borrelia burgdorferi N/S	Unknown (null)
Atypical pneumonia	Pharyngitis Tracheobronchitis	Mycoplasma pneumoniae N/S Mycoplasma pneumoniae N/S	Unknown (null)
Birth defects	Toxoplasmosis	Toxoplasma gondii N/S Toxoplasma gondii N/S Toxoplasma gondii N/S	Systemic (null) Central nervous system (null)
Blindness	Toxoplasmosis	Toxoplasma gondii N/S Toxoplasma gondii N/S Toxoplasma gondii N/S	Systemic (null) Central nervous system (null)
Bloody diarrhoea	Hemorrhagic colitis	Escherichia coli Bi 135 A O157:H7	Unknown (null)
Bloody stool	Amebiasis	Entamoeba histolytica HM1-IMSS Entamoeba histolytica N/S Entamoeba histolytica N/S	Unknown (null)
Bloody urine	Cystitis Acute cystitis	Escherichia coli 346 Escherichia coli 6883 Escherichia coli N/S	Urinary bladder (null)
Bronchitis	Taiwan acute respiratory agent	Chlamydia pneumoniae N/S	Unknown (null)
Chest pain	Melioidosis	Burkholderia pseudomallei H-99 Burkholderia pseudomallei Sp-140 Burkholderia pseudomallei Sp-186 Burkholderia pseudomallei Sp-335 Burkholderia pseudomallei U-232	Pharyngeal epithelial cells (Human)
Chills	Pneumonia Legionnaires' disease Malaria	Legionella pneumophila N/S Legionella pneumophila N/S Plasmodium falciparum N/S Plasmodium falciparum N/S Plasmodium falciparum N/S	Unknown (null)
Chronic inflammation	Chronic gastritis Peptic ulcers Gastric cancer	Helicobacter pylori CCUG 17875 Helicobacter pylori CCUG 17874 Helicobacter pylori CCUG 17875 Helicobacter pylori J99 Helicobacter pylori J99/NAP- Helicobacter pylori NCTC 11637 Helicobacter pylori P466 Helicobacter pylori N/S Helicobacter pylori 032 Helicobacter pylori N/S Helicobacter pylori N/S Helicobacter pylori N/S Helicobacter pylori N/S Helicobacter pylori N/S	Stomach (Human)
Cloudy cornea	Trachoma	Chlamydia trachomatis N/S	Unknown (null)
Cloudy urine	Cystitis Acute cystitis	Escherichia coli 346 Escherichia coli 6883 Escherichia coli N/S	Urinary bladder (null)
Colitis	Shigellosis	Shigella dysenteriae N/S Shiga toxin	Unknown (null)
Conjunctivis	Trachoma	Chlamydia trachomatis N/S	Unknown (null)
Death	Pleuropneumonia Porcine fibrinohemorrhagic necrotizing pleuropneumonia	Actinobacillus pleuropneumoniae Serotype 1 Actinobacillus pleuropneumoniae Serotype 2	Lung (Swine)
Dental caries	Actinomycosis	Actinomyces naeslundii N/S Actinomyces naeslundii N/S Actinomyces naeslundii WVU45 Actinomyces naeslundii N/S Actinomyces naeslundii ATCC 12104 Actinomyces naeslundii WVU45	Unknown (null) Oral cavity (null) Oral epithelial (null)
Diarrhea	Pneumonia Legionnaires' disease Diarrhea Clostridial myonecrosis	Clostridium perfringens N/S Delta toxin Escherichia coli N/S Legionella pneumophila N/S Legionella pneumophila N/S	Integumentary (null) Unknown (null) Digestive system (null)
Encephalopathy	Malaria	Plasmodium falciparum N/S Plasmodium falciparum N/S Plasmodium falciparum N/S	Unknown (null)
Erythema	Lyme disease	Borrelia burgdorferi N/S	Unknown (null)
Eye discharge	Trachoma	Chlamydia trachomatis N/S	Unknown (null)
Fatal encephalitis	Toxoplasmosis	Toxoplasma gondii N/S Toxoplasma gondii N/S Toxoplasma gondii N/S	Systemic (null) Central nervous system (null)
Fatigue	Lyme disease	Borrelia burgdorferi N/S	Unknown (null)
Fetal infant mortality	Toxoplasmosis	Toxoplasma gondii N/S Toxoplasma gondii N/S Toxoplasma gondii N/S	Systemic (null) Central nervous system (null)
Fever	Lyme disease Melioidosis Pyelonephritis Pneumonia Legionnaires' disease Pharyngitis Malaria Clostridial myonecrosis Tracheobronchitis Amebiasis	Escherichia coli PN7 Escherichia coli R45 Escherichia coli Recombinant HB101(pPIL 219-15) Escherichia coli Recombinant HB101 Clostridium perfringens N/S Delta toxin Escherichia coli N/S Borrelia burgdorferi N/S Plasmodium falciparum N/S Plasmodium falciparum N/S Plasmodium falciparum N/S Burkholderia pseudomallei H-99 Burkholderia pseudomallei Sp-140 Burkholderia pseudomallei Sp-186 Legionella pneumophila N/S Burkholderia pseudomallei Sp-335 Legionella pneumophila N/S Burkholderia pseudomallei U-232 Entamoeba histolytica HM1-IMSS Entamoeba histolytica N/S Entamoeba histolytica N/S Mycoplasma pneumoniae N/S Mycoplasma pneumoniae N/S Escherichia coli IA2(pDC1) Escherichia coli IA2 Escherichia coli IH11165 Escherichia coli J96 HB101/pPAP5 Escherichia coli J96(JJ122) Escherichia coli J96(pJFK102) Escherichia coli J96	Unknown (null) Digestive system (null) Pharyngeal epithelial cells (Human) Integumentary (null) Kidney (Human)
Flank pain	Pyelonephritis	Escherichia coli PN7 Escherichia coli R45 Escherichia coli Recombinant HB101(pPIL 219-15) Escherichia coli Recombinant HB101 Escherichia coli N/S Escherichia coli IA2(pDC1) Escherichia coli IA2 Escherichia coli IH11165 Escherichia coli J96 HB101/pPAP5 Escherichia coli J96(JJ122) Escherichia coli J96(pJFK102) Escherichia coli J96	Unknown (null) Kidney (Human)
Flu-like symptoms	Malaria	Plasmodium falciparum N/S Plasmodium falciparum N/S Plasmodium falciparum N/S	Unknown (null)
Forceful vomiting	Gastroenteritis	Norovirus norwalk virus Boxer Norovirus norwalk virus BUDS Norovirus norwalk virus GrV Norovirus norwalk virus GrV or VA207 Norovirus norwalk virus HV Norovirus norwalk virus MOH Norovirus norwalk virus MxV Norovirus norwalk virus NV Norovirus norwalk virus OIF Norovirus norwalk virus PiV Norovirus norwalk virus VA207 Norovirus norwalk virus VA387 Rotavirus Human rotavirus P[14] HAL1166 Rotavirus Unclassified Rotavirus A RRV Norovirus norwalk virus GII.12 Rotavirus Bovine rotavirus A NCDV/G6 Rotavirus Human Rotavirus A Human Rotavirus G3P[6] Rotavirus Simian rotavirus A SA11 Rotavirus Bovine rotavirus A UK/G6	Small intestine (Human) Colonic epithelium (Human)
Gastric cancer	Chronic gastritis Peptic ulcers Gastric cancer	Helicobacter pylori CCUG 17875 Helicobacter pylori CCUG 17874 Helicobacter pylori CCUG 17875 Helicobacter pylori J99 Helicobacter pylori J99/NAP- Helicobacter pylori NCTC 11637 Helicobacter pylori P466 Helicobacter pylori N/S Helicobacter pylori 032 Helicobacter pylori N/S Helicobacter pylori N/S Helicobacter pylori N/S Helicobacter pylori N/S Helicobacter pylori N/S	Stomach (Human)
Headache	Lyme disease Histoplasmosis Pneumonia Legionnaires' disease	Legionella pneumophila N/S Borrelia burgdorferi N/S Legionella pneumophila N/S Histoplasma capsulatum CDC B923 Histoplasma capsulatum IMT 55	Unknown (null)
Hemolytic-uremic syndrome	Shigellosis Hemorrhagic colitis	Shigella dysenteriae N/S Shiga toxin Escherichia coli Bi 135 A O157:H7	Unknown (null)
Inflammation and breakdown of periodontal tissues	Lazy leukocyte syndrome	Streptococcus gordonii DL1 Actinomyces naeslundii WVU45	Polymorphonuclear leukocyte (Human) Periodontium (Human)
Kidney failure	Hemorrhagic colitis	Escherichia coli Bi 135 A O157:H7	Unknown (null)
Loss of appetite	Histoplasmosis	Histoplasma capsulatum CDC B923 Histoplasma capsulatum IMT 55	Unknown (null)
Lower respiratory tract infections	Taiwan acute respiratory agent	Chlamydia pneumoniae N/S	Unknown (null)
Malaise	Pharyngitis Tracheobronchitis	Mycoplasma pneumoniae N/S Mycoplasma pneumoniae N/S	Unknown (null)
Meningitis	Lyme disease	Borrelia burgdorferi N/S	Unknown (null)
Muscular paralysis	Botulism	Clostridium botulinum Serotype A Neurotoxin type A Clostridium botulinum Serotype A Progenitor toxin type A Clostridium botulinum Serotype C Neurotoxin Clostridium botulinum Serotype C Progenitor toxin type C Clostridium botulinum Serotype D, OFD05 Neurotoxin Clostridium botulinum Serotype F Neurotoxin F Clostridium botulinum Serotype G Neurotoxin Clostridium botulinum N/S Neurotoxin type A Clostridium botulinum N/S Neurotoxin type B	Unknown (null) Nervous system (Bovine)
Myalgia	Lyme disease Histoplasmosis	Borrelia burgdorferi N/S Histoplasma capsulatum CDC B923 Histoplasma capsulatum IMT 55	Unknown (null)
Nausea	Pyelonephritis Gastroenteritis	Escherichia coli PN7 Escherichia coli R45 Escherichia coli Recombinant HB101(pPIL 219-15) Norovirus norwalk virus Boxer Norovirus norwalk virus BUDS Escherichia coli Recombinant HB101 Norovirus norwalk virus GrV Norovirus norwalk virus GrV or VA207 Norovirus norwalk virus HV Norovirus norwalk virus MOH Norovirus norwalk virus MxV Norovirus norwalk virus NV Norovirus norwalk virus OIF Norovirus norwalk virus PiV Norovirus norwalk virus VA207 Norovirus norwalk virus VA387 Escherichia coli N/S Rotavirus Human rotavirus P[14] HAL1166 Rotavirus Unclassified Rotavirus A RRV Norovirus norwalk virus GII.12 Rotavirus Bovine rotavirus A NCDV/G6 Escherichia coli IA2(pDC1) Rotavirus Human Rotavirus A Human Rotavirus G3P[6] Rotavirus Simian rotavirus A SA11 Escherichia coli IA2 Rotavirus Bovine rotavirus A UK/G6 Escherichia coli IH11165 Escherichia coli J96 HB101/pPAP5 Escherichia coli J96(JJ122) Escherichia coli J96(pJFK102) Escherichia coli J96	Unknown (null) Colonic epithelium (Human) Kidney (Human) Small intestine (Human)
Nonproductive cough	Histoplasmosis Pneumonia Legionnaires' disease	Legionella pneumophila N/S Legionella pneumophila N/S Histoplasma capsulatum CDC B923 Histoplasma capsulatum IMT 55	Unknown (null)
Often fatal post-weaning diarrhea	-	-	-
Opisthotonus	Tetanus	Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin	Central nervous system (null)
Oral infections	Actinomycosis	Actinomyces naeslundii N/S Actinomyces naeslundii N/S Actinomyces naeslundii WVU45 Actinomyces naeslundii N/S Actinomyces naeslundii ATCC 12104 Actinomyces naeslundii WVU45	Unknown (null) Oral cavity (null) Oral epithelial (null)
Painful urination	Cystitis Acute cystitis	Escherichia coli 346 Escherichia coli 6883 Escherichia coli N/S	Urinary bladder (null)
Peptic ulceration	Chronic gastritis Peptic ulcers Gastric cancer	Helicobacter pylori CCUG 17875 Helicobacter pylori CCUG 17874 Helicobacter pylori CCUG 17875 Helicobacter pylori J99 Helicobacter pylori J99/NAP- Helicobacter pylori NCTC 11637 Helicobacter pylori P466 Helicobacter pylori N/S Helicobacter pylori 032 Helicobacter pylori N/S Helicobacter pylori N/S Helicobacter pylori N/S Helicobacter pylori N/S Helicobacter pylori N/S	Stomach (Human)
Periodontal disease	Actinomycosis	Actinomyces naeslundii N/S Actinomyces naeslundii N/S Actinomyces naeslundii WVU45 Actinomyces naeslundii N/S Actinomyces naeslundii ATCC 12104 Actinomyces naeslundii WVU45	Unknown (null) Oral cavity (null) Oral epithelial (null)
Pneumonia	Taiwan acute respiratory agent	Chlamydia pneumoniae N/S	Unknown (null)
Primary root caries	Actinomycosis	Actinomyces naeslundii N/S Actinomyces naeslundii N/S Actinomyces naeslundii WVU45 Actinomyces naeslundii N/S Actinomyces naeslundii ATCC 12104 Actinomyces naeslundii WVU45	Unknown (null) Oral cavity (null) Oral epithelial (null)
Profuse watery diarrhea	Cholera	Vibrio cholerae N/S Toxin Vibrio cholerae N/S Toxin Vibrio cholerae N/S Toxin Vibrio cholerae N/S Toxin Vibrio cholerae N/S Toxin Vibrio cholerae N/S Toxin Vibrio cholerae ATCC 14034 Vibrio cholerae ATCC 14035 Vibrio cholerae O1 Vibrio cholerae N/S	Unknown (null)
Respiratory distress	Melioidosis	Burkholderia pseudomallei H-99 Burkholderia pseudomallei Sp-140 Burkholderia pseudomallei Sp-186 Burkholderia pseudomallei Sp-335 Burkholderia pseudomallei U-232	Pharyngeal epithelial cells (Human)
Respiratory failure	Botulism	Clostridium botulinum Serotype A Neurotoxin type A Clostridium botulinum Serotype A Progenitor toxin type A Clostridium botulinum Serotype C Neurotoxin Clostridium botulinum Serotype C Progenitor toxin type C Clostridium botulinum Serotype D, OFD05 Neurotoxin Clostridium botulinum Serotype F Neurotoxin F Clostridium botulinum Serotype G Neurotoxin Clostridium botulinum N/S Neurotoxin type A Clostridium botulinum N/S Neurotoxin type B	Unknown (null) Nervous system (Bovine)
Respiratory tract infection	Pleuropneumonia Melioidosis Porcine fibrinohemorrhagic necrotizing pleuropneumonia	Actinobacillus pleuropneumoniae Serotype 1 Actinobacillus pleuropneumoniae Serotype 2 Burkholderia pseudomallei H-99 Burkholderia pseudomallei Sp-140 Burkholderia pseudomallei Sp-186 Burkholderia pseudomallei Sp-335 Burkholderia pseudomallei U-232	Lung (Swine) Pharyngeal epithelial cells (Human)
Secondary enamel caries	Actinomycosis	Actinomyces naeslundii N/S Actinomyces naeslundii N/S Actinomyces naeslundii WVU45 Actinomyces naeslundii N/S Actinomyces naeslundii ATCC 12104 Actinomyces naeslundii WVU45	Unknown (null) Oral cavity (null) Oral epithelial (null)
Severe cough	Pharyngitis Tracheobronchitis	Mycoplasma pneumoniae N/S Mycoplasma pneumoniae N/S	Unknown (null)
Severe coughing	Pertussis	Bordetella pertussis Bordetella pertussis N/S Bordetella pertussis N/S Toxin	Unknown (null)
Severe disseminated disease	Toxoplasmosis	Toxoplasma gondii N/S Toxoplasma gondii N/S Toxoplasma gondii N/S	Systemic (null) Central nervous system (null)
Severe dysentery	Shigellosis	Shigella dysenteriae N/S Shiga toxin	Unknown (null)
Stomach pain	Melioidosis Amebiasis	Burkholderia pseudomallei H-99 Burkholderia pseudomallei Sp-140 Burkholderia pseudomallei Sp-186 Burkholderia pseudomallei Sp-335 Burkholderia pseudomallei U-232 Entamoeba histolytica HM1-IMSS Entamoeba histolytica N/S Entamoeba histolytica N/S	Unknown (null) Pharyngeal epithelial cells (Human)
Subtle psychiatric manifestations	Toxoplasmosis	Toxoplasma gondii N/S Toxoplasma gondii N/S Toxoplasma gondii N/S	Systemic (null) Central nervous system (null)
Tetanic convulsion	Tetanus	Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin	Central nervous system (null)
Tetany	Tetanus	Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin Clostridium tetani N/S Tetanus neurotoxin	Central nervous system (null)
Throbbing headache	Pharyngitis Tracheobronchitis	Mycoplasma pneumoniae N/S Mycoplasma pneumoniae N/S	Unknown (null)
Trichiadis	Trachoma	Chlamydia trachomatis N/S	Unknown (null)
Upper respiratory tract infections	Vincent's angina	Fusobacterium nucleatum N/S	Unknown (null)
Vomiting	Pertussis Clostridial myonecrosis	Bordetella pertussis Bordetella pertussis N/S Clostridium perfringens N/S Delta toxin Bordetella pertussis N/S Toxin	Unknown (null) Integumentary (null) Digestive system (null)
Watery diarrhea	Gastroenteritis	Norovirus norwalk virus Boxer Norovirus norwalk virus BUDS Norovirus norwalk virus GrV Norovirus norwalk virus GrV or VA207 Norovirus norwalk virus HV Norovirus norwalk virus MOH Norovirus norwalk virus MxV Norovirus norwalk virus NV Norovirus norwalk virus OIF Norovirus norwalk virus PiV Norovirus norwalk virus VA207 Norovirus norwalk virus VA387 Rotavirus Human rotavirus P[14] HAL1166 Rotavirus Unclassified Rotavirus A RRV Norovirus norwalk virus GII.12 Rotavirus Bovine rotavirus A NCDV/G6 Rotavirus Human Rotavirus A Human Rotavirus G3P[6] Rotavirus Simian rotavirus A SA11 Rotavirus Bovine rotavirus A UK/G6	Small intestine (Human) Colonic epithelium (Human)
Widespread epithelial tissue infections	Candidiasis Cryptococcosis Histoplasmosis Sporotrichosis	Cryptococcus neoformans ATCC 34877 Cryptococcus neoformans HFH 32 Cryptococcus neoformans IMT 43 Cryptococcus neoformans NIH 68A Candida albicans ATCC 18804 Candida albicans HFH 44 Candida albicans HFH 45 Candida albicans N/S Sporothrix schenckii CDC B4668 Sporothrix schenckii IMT58 Histoplasma capsulatum CDC B923 Histoplasma capsulatum IMT 55	Unknown (null)

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